Endocrine Abstracts

Introduction: The 48XXXY karyotype is an infrequent (incidence about 1/50000 male births) sporadic aneuploidy of the sex chromosomes, classically considered as a variant of the Klinefelter syndrome (47XXY). Although many of their characteristics are shared, patients with the 48XXXY karyotype suffer from additional endocrinological and neuropsychological disturbances which are not part of the classic Klinefelter syndrome. Hereby we present a clinical case.<p class="abstext"...

Introduction: Oral semaglutide has been available in the Spanish market since November 2021. This new formulation has broken the self-injection barrier, and may enhance patient satisfaction.Methods: Retrospective review of the patients′ records and presential or telephonic interviews. All patients expressed their consent for the anonymous processing of their data. Numeric data are given as mean + s.d; paired t-test was used for comparison. Satisfac...

Introduction: It has been reported that patients with obesity and T2DM treated with oral semaglutide not only have a reduced total caloric input, but they also tend to reduce the proportion of fatty and sweet foodstuffs in an ad libitum diet. A modest improvement in the lipid profile of patients with obesity and T2DM treated with oral semaglutide has been reported, but its dependence on weight loss is not well established. We undertook to study the mediation effect of...

Introduction: Extended-release (ER) metformin has been available in many countries for the last two decades, and it may have definite advantages vs. conventional (i.e., immediate-release) metformin: Reportedly, it may reduce gastrointestinal adverse effects by about half, thus increasing compliance; moreover, the once-a-day schedule may contribute to increased adherence and persistence, and hopefully improved outcomes. However, ER metformin was unavailable in Spain until 2022:...

Introduction: The Neuroendocrine Tumors Study Group of the Portuguese Endocrine Society (SPEDM) performed the first observational study between November 2012 and July 2014 too assess the profile of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NET) patients (pts) followed at the main Portuguese hospitals. Several demographic and clinical data were collectedObjective: Characterize the clinicopathological features and treatment of patients with NET or...

Introduction: Silymarin is a standardized extract of the milk thistle (Sylibum marianum) seeds, containing a mixture of flavonolignans: silybinin, isosilybinin, silycristin, silydianin, and others. It is used in the treatment of toxic liver damage and as adjunctive therapy in chronic hepatitis and cirrhosis. Recent studies have shown a potential benefit in the treatment of diabetes mellitus and non-alcoholic fatty liver disease. We undertook to study the effect of silymarin on...

Objectives: Understanding and propagating the knowledge of the burden caused by the massive infradiagnosis of Primary Aldosteronism (PA), partly due to unawareness of its high prevalence and partly to the complexity of its screening in Primary Care and workup in Specialized Care.Methods: Review of the relevant literature and personal reflections.Results: PA is the first cause of secondary hypertension and a highly prevalent disease...

IntroductionCarney Complex is a rare syndrome characterized by lentiginosis cutis and/or blue nevi, multiple endocrine neoplasia and non-endocrine tumors (cutaneous, mucosal, mammary or cardiac myxomata, bone osteochondromyxoma, psammomatous melanotic schwannoma, multiple ovarian cysts, multiple mammary ductal adenoma). Most cases are familiar, with autosomal dominant heredity and penetrance close to 100%. It is caused by a variety of mutations that acti...

IntroductionMany transsexual patients are concerned about the risk of cancer associated with hormonal gender-affirming therapy. However, the general risk seems to be very low. We hereby report the case of a strikingly large gastrointestinal stromal tumor (GIST) in a male-to-female transsexual patient, after 25 years of hormonal therapy.MethodsReview of the patient’s clinical records and the relevant lite...

IntroductionVitamin D deficiency is associated with higher risk of COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (81.0% < 30 ng/ml plasma calcifediol) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown in Northern Gran Canaria. During the winter period (December 2020 to February 2021) some restrictions for social gatherings and a nightly curfew have been en...